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Programme on Biology of Sepsis

Sepsis is a potentially fatal systematic inflammation of the whole-body. It can continue even after the infection that caused it is gone and prompt diagnosis is crucial to its management. The division has been discussing and deliberating at various forums to develop a collaborative programme on Sepsis Biology with the involvement of Indian and International experts. Sepsis is a deranged expression of innate immune system and most common cause of morbidity and mortality in ICU settings. Rapid treatment of sepsis is of crucial importance for survival of patients. Specific and rapid markers of bacterial infection are required for early diagnosis and treatment of sepsis. The programme would be developed for both adult and pediatric sepsis with focus on infectious as well as chronic diseases.

Some Research Questions
  • Which individual biomarkers or groups of biomarkers at the time of initial presentation predict failure to respond to early intervention, and an increased risk of new organ dysfunction and ultimate mortality?
  • What clinical features present early in the course of illness predict a failure to respond to early intervention, and an increased risk of new organ dysfunction and death?
  • What microbiologic factors predict failure to respond, new organ dysfunction, and death?
  • What clinical variables present early in the course of disease predict each of the specific characteristic late complications of sepsis including nosocomial infection, prolonged cardiovascular dysfunction, acute respiratory distress syndrome (ARDS), and acute renal failure?
  • To what extent do the above predictors vary from one country to the next?