Membrane proteins and their complexes play crucial roles in many cellular and physiological processes. They are essential mediators of material, information, and energy transfer between cells and their environment, between compartments within the cell, and between compartments comprising the organ systems. Functionally normal membrane proteins are vital to health, and specific defects are associated with many known disease states. Membrane proteins are the targets of a large number of pharmacologically and toxicologically active substances and are responsible, in part, for their uptake, metabolism, and clearance.
Extensive research is ongoing in the area of membrane protein structure and function, yet relatively few investigators have successfully applied the techniques of x-ray crystallography, electron microscopy, or NMR spectroscopy to solve the high resolution structures of their proteins due to the intrinsic challenges. Even though 30-40% protein of the cells are known to be membrane proteins, yet only approximately 100 unique membrane protein structures have been solved, and each structure has made a major contribution in its respective area of science. Therefore, it is apparent that a special effort is needed to promote studies of membrane protein structures. An increase in the number of known membrane protein structures will contribute to an enhanced understanding of many basic phenomena underlying cellular functions important to human health.
To encourage and nurture multidisciplinary and collaborative research the Department of Biotechnology through this call invites proposals built upon innovative ideas in the areas of “Structural Biology of Membrane Proteins” by undertaking research including but not limited to the following areas:
1) Plant and animal organelle membrane proteins such as nucleus, golgi, chloroplast etc.
2) Bacterial and viral membrane proteins and their complexes with host factors
3) Multi-protein assembles on cell membranes in various physiological processes
4) Transmembrane proteins in human diseases and drug discovery
5) Cell surface protein and ligand assemblies involved in important physiological processes etc.
Eligibility: Applications may be submitted by public and private universities, colleges, Institutes, non-profit organizations (recognized by DSIR as a Scientific and Industrial Research Organization (SIRO). It is expected that some of the projects will be collaborative efforts between and among chemists, biochemists, molecular biologists, and biophysicists with expertise in the synthesis of probes, novel solubilizing and stabilizing reagents; cloning and expression; isolation and characterization of membrane-bound proteins; and in x-ray crystallography, NMR, and other structural methods.
How to apply and Assessment criteria: Applicants should submit soft copy of concept note in the format attached through email: firstname.lastname@example.org Two Hard copy of the same to be sent to Dr. Manish Rana, Scientist-E, Department of Biotechnology, Block- 2, Room No.612, 6th floor, CGO Complex, Lodhi Road, New Delhi – 110003.
The deadline for submission of concept note is 15th December, 2017.
Concept Note will be considered by a screening panel comprising external experts and officials from the DBT. Overall, the assessment will be based on the scientific merit, originality/novelty of the proposal, abilities and skills to execute the proposed project besides other criterion. Concept Notes selected by the screening panel will be asked to submit full proposal in DBT format online through e-Promis (www.dbtepromis.nic.in).
For any queries, contact:
Dr. Manish Rana,